• LY364947: Selective TGF-β Type I Receptor Kinase Inhibito...

  2026-01-20

  LY364947 is a potent, selective TGF-β type I receptor kinase inhibitor (IC50 = 51 nM) used to dissect TGF-β signaling and epithelial-mesenchymal transition (EMT) in preclinical research. Its robust suppression of Smad2 phosphorylation and EMT marker modulation positions it as a gold-standard tool for anti-fibrotic and retinal degeneration studies. APExBIO supplies LY364947 in research-grade formats, ensuring reliable experimental outcomes.

• Quizartinib (AC220): Selective FLT3 Inhibitor for Acute M...

  2026-01-20

  Quizartinib (AC220) is a second-generation, highly selective FLT3 inhibitor optimized for acute myeloid leukemia (AML) research. Its nanomolar potency and mechanism-based selectivity make it a benchmark tool for FLT3 signaling pathway interrogation and resistance studies. This article provides atomic, verifiable claims about Quizartinib's activity, selectivity, and practical workflow integration.

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